Indication

Adjunctive treatment for epilepsy refractive to other antiepileptic drugs, in particular absence and myoclonic seizures, and infantile spasms. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia
Acute treatment of status epilepticus

Action

Benzodiazepines potentiate the inhibitory effects of gamma aminobutyric acid (GABA throughout the CNS, resulting in anxiolytic, sedative hypnotic, muscle relaxant and antiepileptic effects. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

Dose advice

Epilepsy:
Adult: initially oral 0.5-1mg at bedtime for 4 days, increase gradually over 2-4 weeks to 2-8mg daily in divided doses
Child: initially oral 0.01-0.03mg/kg in divided doses, increase gradually up to 0.1-0.2mg/kg daily
Status epilepticus:
Adult: 1mg by slow IV injection, repeated if necessary
Infant, child: 500mcg by slow IV injection. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

Schedule

S4

Common side effects

Drowsiness
Over-sedation
Light-headedness
Memory loss
Ataxia
Slurred speech

Uncommon side effects

Headache
Vertigo
Hypotension
Disorientation
Confusion
Paradoxical excitation
Euphoria
Aggression and hostility
Anxiety
Decreased libido
Anterograde amnesia
Pain and thrombophlebitis with IV injection
Respiratory arrest with IV use

Paxam Rosemont Oral Solution is indicated in all clinical forms of epileptic disease and seizures in adults, especially absence seizures (petit mal) including atypical absence; primary or secondarily generalised tonic-clonic (grand mal), tonic or clonic seizures; partial (focal) seizures with elementary or complex symptomatology; various forms of myoclonic seizures, myoclonus and associated abnormal movements. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

Dosage (Posology) and method of administration

Posology

The 0.5mg/5ml oral solution may facilitate the administration of lower daily doses in the initial stages of treatment or treatment for the elderly.

The 2mg/5ml oral solution should be used for maintenance and maximum dosage regimens.

Adults

Initial dosage should not exceed 1mg/day. The maintenance dosage for adults normally falls within the range 4 to 8mg.

Elderly

The elderly are particularly sensitive to the effects of centrally depressant drugs and may experience confusion. It is recommended that the initial dosage of Paxam should not exceed 0.5mg/day. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

These are total daily dosages which should be divided into 4 doses taken at intervals throughout the day. If necessary, larger doses may be given at the discretion of the physician, up to a maximum of 20mg daily. The maintenance dose should be attained after 2 to 4 weeks of treatment.

Paediatric Population

Due to the presence of ethanol in the formulation, this product is not indicated for paediatric use.

Method of administration

A 2.5ml/ 5ml double ended spoon with a further 1.25ml graduation is supplied with the pack.

Suitable for administration via non-PVC nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG) tubes. When these instructions are followed over 95% of the dose is delivered.

The product is incompatible with polystyrene or PVC and therefore, other devices may react with the product.

It should be noted that for oral syringes, the product may cause the plunger to stop moving smoothly or the markings may fade over time. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

Treatment should be started with low doses. The dose may be increased progressively until the maintenance dose suited to the individual patient has been found.

The dosage of Paxam must be adjusted to the needs of each individual and depends on the individual response to therapy. The maintenance dosage must be determined according to clinical response and tolerance.

The daily dose should be divided into 4 equal doses. If doses are not equally divided, the largest dose should be given before retiring. Once the maintenance dose level has been reached, the daily amount may be given in a single dose in the evening. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia

Simultaneous administration of more than one antiepileptic drug is a common practice in the treatment of epilepsy and may be undertaken with Paxam. The dosage of each drug may be required to be adjusted to obtain the optimum effect. If status epilepticus occurs in a patient receiving oral Paxam, administration of an intravenous Paxam injection may still control the status. Before adding Paxam to an existing anticonvulsant regimen, it should be considered that the use of multiple anticonvulsants may result in an increase of undesired effects. Buy Paxam 2 Clonazepam 2mg online in New Zealand and Australia